2021 Mercedes-Benz E 350 Recalls, Problems & Safety Rating

12 safety recalls on file

The 2021 Mercedes-Benz E 350 has 12 safety recalls on file with NHTSA.

Owners have filed 13 complaints with NHTSA, including 1 fire.

The most-reported problem area is Back Over Prevention (5 reports).

12Recalls
13Owner complaints
0Crashes reported
n/aNHTSA safety rating
Is the repair still open on your E 350?

A recall covers specific vehicles. Your VIN shows whether yours still needs the free repair.

2021 Mercedes-Benz E 350 recalls

Fuel Pump May Shut Off, Causing Loss of Power

Recall 23V445Jun 26, 2023143,551 vehicles affected

The fuel pump in these vehicles may shut down while driving.

Emergency call system may fail to connect in a crash

Recall 22V365May 20, 2022242,722 vehicles affected

A software error in the communication module's SIM card can cause a mobile network connection failure.

Rearview camera may show no image, raising crash risk

Recall 22V232Apr 8, 2022126,443 vehicles affected

The rearview camera may fail to display the rear view because of a software error.

Steering Hands-Off Detection May Fail, Raising Crash Risk

Recall 22V189Mar 25, 20228,396 vehicles affected

A software error in the hand detection control unit can keep the hands-off detection from recognizing when the driver's hands are off the steering wheel while the Active Distance Assist DISTRONIC system is in use.

Loose Side Sensor Connectors Can Delay Airbags in a Crash

Recall 21V527Jul 12, 2021542 vehicles affected

Side crash sensor connectors in certain vehicles may come loose.

Rear seat belts may loosen child seat hold in a crash

Recall 21V483Jun 25, 20214,917 vehicles affected

Certain 2021 Mercedes-Benz AMG and CLS models have rear seat belt automatic locking retractors that may deactivate early.

Rearview camera may show a blank screen, raising crash risk

Recall 21V354May 14, 2021343,191 vehicles affected

The multimedia system software in these vehicles can cause the infotainment display to stay black or reboot after startup.

Rearview Camera May Fail, Raising Backover Crash Risk

Recall 21V228Apr 1, 20216 vehicles affected

The parking control unit in certain 2021 Mercedes-Benz E 350, E 450, and AMG E63 vehicles may fail to display the rearview camera image.

Air Bags and Seat Belts May Not Deploy in a Crash

Recall 21V230Apr 1, 20218,634 vehicles affected

A faulty electrical contact in the seat position switch can stop the driver and passenger air bags and the seat belt force limiters from activating properly during a crash.

Passenger seat can move too close to airbag

Recall 21V216Mar 26, 2021109 vehicles affected

The passenger seat's position limiter may allow the seat to be moved too close to the front passenger airbag.

Crash Alert May Send Responders to Wrong Location

Recall 21V058Feb 5, 20211,292,258 vehicles affected

Certain 2016-2017 Mercedes-Benz vehicles have a software problem in the communication module that runs the automatic crash notification (eCall) system.

Passenger Seat May Move Too Far, Raising Airbag Injury Risk

Recall 20V673Oct 30, 20201,337 vehicles affected

The front passenger seat may be missing the mechanical stop that limits how far it can travel.

Most common 2021 Mercedes-Benz E 350 problems

Problem areas named in the 13 complaints owners filed with NHTSA.

Problem areaReports
Back Over Prevention5
Engine4
Electrical System4
Power Train3
Fuel/Propulsion System2
Fuel System, Gasoline1
Service Brakes1

What owners report

2026-08-08, Power Train
Engine misfires, lower engine power, and a lit check engine/Malfunction Indicator Lamp. Mercedes-Benz issued an Emission Service Campaign (No. 2021070006, internal code 21P1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the E-Class. My VIN was not included in the recall campaign but my vehicle is experiencing these exact symptoms as referenced in the first sentence. My vehicle has 48,000 miles.
2026-05-08, Electrical System
Vehicle: 2021 Mercedes-Benz E350 Sedan (W213) VIN: [XXX] While operating the vehicle, the diagnostic system displayed the fault code P240200 related to the Evaporative Emission Control System (EVAP). The warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. The malfunction appears to involve the EVAP diagnostic module and/or associated electrical wiring near the fuel system. The affected component may be available for inspection upon request. The issue raises safety concerns because the fault involves an electrical short circuit associated with the fuel vapor control system. Potential risks may include electrical overheating, malfun
2026-01-04, Power Train
With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .
2025-12-27, Engine
Engine keeps having a misfire that Mercedes put a TSB out for and once the misfire happen I cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. The car had 54K miles and Mercedes refused to repair the issue as the engine part failure isn’t common.
2025-07-14, Engine
My 2021 Mercedes-Benz E350 (VIN [XXX] ) developed a serious engine issue involving cylinder misfire and check engine light. The dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to TSB LI01.30-P-072328, which documents valve seat wear in M260 engines. This is a known defect acknowledged by Mercedes in technical bulletins, and other customers in the U.S. have received warranty extensions or goodwill coverage. I was denied coverage even though this is a manufacturer defect that can lead to misfire, power loss, and potential stalling, posing a safety risk on the road. Mercedes-Benz USA refuses to cover the repair (~$7,600+), even though it relates to a factory-documented p

2021 Mercedes-Benz E 350 questions

Does the 2021 Mercedes-Benz E 350 have any recalls?

Yes. NHTSA lists 12 safety recalls for the 2021 Mercedes-Benz E 350: Fuel Pump May Shut Off, Causing Loss of Power; Emergency call system may fail to connect in a crash; Rearview camera may show no image, raising crash risk; Steering Hands-Off Detection May Fail, Raising Crash Risk; Loose Side Sensor Connectors Can Delay Airbags in a Crash. Recall repairs are normally free at an authorized dealer.

What are the most common problems with the 2021 Mercedes-Benz E 350?

Based on 13 owner complaints filed with NHTSA, the most-reported problem areas are Back Over Prevention (5), Engine (4), Electrical System (4).

How do I check if a recall on my 2021 Mercedes-Benz E 350 has been fixed?

Enter your 17-character VIN in our VIN recall check. It shows open recalls that have not been repaired on your specific vehicle. Recall repairs are normally free at an authorized dealer.

Other Mercedes-Benz E 350 years

Other 2021 Mercedes-Benz models